Mepivacaine hydrochloride polymorphs: a drug production quandary
نویسندگان
چکیده
منابع مشابه
Paroxetine hydrochloride: polymorphs and solvatomorphs.
The polymorphic (crystal systems for which a substance can exist in structures defined by different unit cells, and where each of the forms has the same elemental composition) and solvatomorphic (systems where the crystal structures of the substance are defined by different unit cells, but where these unit cells differ in their elemental composition through the inclusion of one or molecules of ...
متن کاملThermoreversibal anesthetic gel for periodontal intrapocket delivery of mepivacaine hydrochloride
Objective of the present study was to develop and evaluate thermoreversible in situ gelling drug delivery system for periodontal anasthesia. This system improves patient compliance by giving anesthesia at a site without distress of needle insertion. Thermoreversible gels were prepared by combining different concentration of pluronics F127 and F68. Formulations were evaluated in terms of their v...
متن کاملPhase Transitions of Ipidacrine Hydrochloride Polymorphs and Hydrates
Ipidacrine hydrochloride is pharmaceutically active compound that forms variety of crystalline modifications which differs by solvent type and content in crystalline structure. These crystalline forms analyzed by powder x-ray diffraction, differential thermal analysis, thermogravimetry and Karl Fisher titration. Obtained crystalline forms include two monohydrates, two hemihydrates, two anhydrou...
متن کاملA Stability Indicating Hplc Method for the Determination of Mepivacaine Hydrochloride
Stability indicating HPLC method has been developed for specific determination of Mepivacaine hydrochloride during degradation under acid, alkali, thermal and oxidative stress conditions. Methanol: Orthophosphoric acid solution (2.25 gm/L) adjusted to pH 7.6 with strong sodium hydroxide solution (75:25), was used as the mobile phase, at a flow rate of 1 ml/min. A Gracesmart C18 column (5μ), 250...
متن کاملIdentification of Drug Polymorphs in Tablets
Polymorphs of an Active Pharmaceutical Ingredient (API) can have different chemical and physical properties and, thus, a direct impact on the processability of the drug substance and the quality/performance of the drug product, such as stability, dissolution, and bioavailability. Therefore, identification of the crystal phase of an API is of outmost importance. In this work methodologies were d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2005
ISSN: 0108-7673
DOI: 10.1107/s0108767305079705